You Position: Home > Paper
Metformin down-regulates the expression of regulators of G protein signaling in OLETF rats
( views:171, downloads:36 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 1
- DOI:
- 10.3969/j.issn.1006-6187.2010.01.016
- Key Word:
- G蛋白信号调节因子;OLETF大鼠;二甲双胍;糖尿病,2型
Abstract： 目的 研究OLETF大鼠G蛋白信号调节因子(RGS)的表达及二甲双胍对其表达的影响.方法设LETO大鼠为对照组(Con组,n=6),OLETF大鼠随机分为糖尿病组(DM组,n=6)和二甲双胍治疗组(Met组,n=5).Con组和DM组予无菌蒸馏水灌胃;Met组予二甲双胍.提取28周大鼠组织总RNA,逆转录后用实时定量PCR方法 检测胸主动脉和左心室RGS2、RGS3和RGS4 mRNA的表达.结果 DM组胸主动脉和左心室RGS2、RGS3和RGS4 mRNA水平显著高于Con组(P<0.01).Met组胸主动脉和左心室RGS2、RGS3和RGS4 mRNA水平显著低于DM组和Con组(P<0.01). 结论 OLETF大鼠胸主动脉和左心室RGS2、RGS3和RGS4 mRNA的升高与糖尿病心血管病变相关;降低则与二甲双胍的作用相关.
- [1]Kosegawa Itaru,Katayama Shigehiro,Kikuchi Chitose,etc.Metformin Decreases Blood Pressure and Obesity in OLETF Rats Via Improvement of Insulin Resistance.[J].1996.
- [2]K, Yagi,S, Kim,H, Wanibuchi,etc.Characteristics of diabetes, blood pressure, and cardiac and renal complications in Otsuka Long-Evans Tokushima Fatty rats.[J].1997,29.
- [3]Saito K,Hongo M,Ishizaka N,etc.Comparison of vasculoprotective effects of benidipine and losartan in a rat model of metabolic syndrome.[J].2008,587(1).
- [4]Huang X,Kaur K,MacDougald OA,etc.Resistance to diet-induced obesity and improved insulin sensitivity in mice with a regulator of G protein signaling-insensitive G184S Gnai2 allele.[J].2008,57(1).
- [5]Kazuya Kawano,Tsukasa Hirashima,Shigehito Mori,etc.OLETF (Otsuka Long-Evans Tokushima Fatty) rat: a new NIDDM rat strain[J].1994,24(1).
- [6]Treskov I,Kelly DP,Rowley MW,etc.G-protein signaling participates in the development of diabetic cardiomyopathy.[J].2004,53(12).
- [7]Xie Z,Bansal G,Druey KM.R4 RGS proteins: Regulation of G-protein signaling and beyond.[J].2007,116(3).