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The effect of endogenous H_2S on the kidney of the diabetic nephropathic rats
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 12
- DOI:
- 10.3969/j.issn.1006-6187.2009.12.021
- Key Word:
- 硫化氢;糖尿病肾病;胱硫醚-β-合成酶;胱硫醚-γ-裂解酶;α平滑肌肌动蛋白;纤维粘连蛋白
Abstract： 目的 内源性硫化氢(H_2S)干预对糖尿病肾病大鼠肾小球病变的影响. 方法 把SD大鼠随机分成4组.建立糖尿病大鼠模型后,其中2组分别给以硫氢化钠和DL-propargylglycine治疗8周.免疫组化法检测肾组织中α平滑肌肌动蛋白(α-SMA)及纤维粘连蛋白(FN)分布及含量的变化. 结果 与H_2S组相比,糖尿病大鼠肾脏中α-SMA和FN的分布范围广泛,含量明显增加(P<0.01). 结论 外源性H_2S干预能够减缓糖尿病大鼠肾小球病变的进展.
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