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Association between the single nucleotide polymorphism of the transcription factor 7-like 2 gene and the genetic susceptibility of type 2 diabetes in Han Chinese population
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 12
- DOI:
- 10.3969/j.issn.1006-6187.2009.12.005
- Key Word:
- 糖尿病,2型;TCF7L2基因;多态性;单核苷酸
Abstract： 目的 探讨TCF7L2基因单核苷酸多态性与汉族人2型糖尿病遗传易感性的关系. 方法 无血缘关系江苏地区汉族人1535例,分为2型糖尿病组(T2DM)、糖耐量减低组(IGT)和正常糖耐量组(NGT),LDR法检测TCF7L2基因rs7903146(C/T)及rs12255372(G/T)单核苷酸多态性. 结果 (1)T2DM、IGT组rs7903146位点T等位基因频率均高于NGT组,但差异无统计学意义;(2)糖代谢异常组rs7903146位点CT基因型频率及T等位基因频率则显著高于NGT组(P均<0.05),T等位基因参与糖代谢异常发生的相对风险为1.589,人群归因危险度为2.1%. 结论 TCF7L2基因单核苷酸多态分布存在明显的种族异质性,rs7903146位点T突变可能是中国汉族人群糖代谢异常发生的遗传因素之一.
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