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Relationship of vitamin D receptor(VDR)FokI gene polymorphism with type 2 diabetes and the combined type 2 diabetes and atherosclerosis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 12
- DOI:
- 10.3969/j.issn.1006-6187.2009.12.004
- Key Word:
- 糖尿病,2型;动脉粥样硬化;基因;易感性;多态性;单核苷酸
Abstract： 目的 探讨维生素D受体(VDR)基因FokI的多态性与T2DM及其合并动脉粥样硬化(AS)之间的相关性. 方法 通过提取全血DNA,PCR扩增VDR基因,FokI酶切扩增产物,检测大连地区T2DM合并AS者(AS组),DM非AS者(non-AS组)及健康对照者(NC组)的基因型.应用单因素非条件logistic回归分析研究VDR基因变异对T2DM及合并AS的影响. 结果 (1)VDR基因FokI酶切位点各基因型在T2DM组和NC组中分布具有统计学差异(P<0.01).(2)AS组和non-AS组VDR基因FokI酶切各基因型分布无统计学差异(P>0.05).(3)VDR等位基因f与T2DM呈显著正相关,等位基因F与T2DM呈显著负相关. 结论 在大连地区的汉族人群中,VDR基因FokI的多态性与T2DM相关,而与T2DM合并AS无关.等位基因f是T2DM的易感基因,而等位基因F对T2DM具有保护作用.
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