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Experimental study on the protection against podocyte injury by simvastatin in diabetes mellitus rats
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 11
- DOI:
- 10.3969/j.issn.1006-6187.2009.11.020
- Key Word:
- 糖尿病肾病;足细胞;辛伐他汀
Abstract： 目的 探讨辛伐他汀对糖尿病大鼠足细胞损伤的保护作用.方法 将糖尿病大鼠模型分三组:正常对照(NC)组、糖尿病未干预(DM)组、辛伐他汀治疗(SVT)组,于第4、8周末检测血肌酐(SCr)、血脂、尿白蛋白排泄率(UAER),观察肾组织病变并计数足突宽度,免疫组化观察去氧肾上腺素、足细胞裂隙膜蛋白、NF-κB、MCP-1表达,Real time-PCR检测mRNA表达.结果 (1)SCr、UAER:DM组>NC组,SVT组<DM组;(2)SVT组肾组织尤其足细胞病变较DM组减轻,足突宽度减低;(3)去氧肾上腺素、足细胞裂隙膜蛋白:DM组<NC组,SVT组>DM组;(4)NF-κB、MCP-1:DM组>NC组,SVT组<DM组,且与去氧肾上腺素、足细胞裂隙膜蛋白呈负相关(P均<0.01).结论 辛伐他汀可能通过降低炎症介质表达维持足细胞相关蛋白分子水平,减轻糖尿病大鼠足细胞损伤.
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