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The myocardial protection by rosiglitazone, atorvastatin, and their combination in rats with type 2 diabetes
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 11
- DOI:
- 10.3969/j.issn.1006-6187.2009.11.019
- Key Word:
- 糖尿病;心肌病;罗格列酮;阿托伐他汀
Abstract： 目的 探讨阿托伐他汀(ATO)和罗格列酮(RGZ)及二者联合对2型糖尿病大鼠心肌胶原堆积的影响.方法 成年SD大鼠,通过高糖、高脂饮食加腹腔注射小剂量STZ制成2型糖尿病大鼠模型,并以ATO(20mg·kg~(-1)·d~(-1))、RGZ(2mg·kg~(-1)·d~(-1))及两药联合进行干预.光镜、电镜观察大鼠心脏的形态学改变及炎症细胞浸润程度,Masson染色观察心肌胶原沉积情况,生化法检测心肌羟脯氨酸含量.结果 RGZ及ATO均可在相似程度上减轻间质胶原沉积,两药联合较任一单药作用更明显(P＜0.01).结论 ATO及RGZ可减轻糖尿病大鼠心肌组织炎症细胞浸润和胶原沉积.二者联合可提高抗炎、抗纤维化程度.
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