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The effect of insulin versus pioglitazone treatment on the platelet function in type 2 diabetics
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 11
- DOI:
- 10.3969/j.issn.1006-6187.2009.11.012
- Key Word:
- 糖尿病;2型;胰岛素;吡格列酮;血小板功能
Abstract： 目的 比较吡格列酮(Pio)、胰岛素(Ins)治疗对T2DM患者血小板功能的影响.方法 经二甲双胍治疗效果不佳的44例新诊断T2DM患者随机分为2组:Ins组在二甲双胍基础上联合皮下注射胰岛素;Pio组在二甲双胍基础上加用吡格列酮.检测0周、4周、24周时各组的FPG、HbA1c、HOMA-IR,血小板膜上GMP-140、PAC-1的表达率及ADP诱导的血小板的聚集率.结果 41例完成治疗.(1)4周后,Pio组FPG高于Ins组,差异有统计学意义;Ins、Pio组间HOMA-IR、ADP诱导的血小板聚集率、血小板GMP-140、PAC-1的表达率差异无统计学意义.(2)24周后,Pio组FPG、 HbA1c高于Ins组;Pio组HOMA-IR、ADP诱导的血小板聚集率、血小板PAC-1、GMP-140的表达率低于Ins组;差异均有统计学意义.结论 胰岛素、吡格列酮治疗均能抑制T2DM患者的血小板功能,但吡格列酮效果优于胰岛素,推测吡格列酮可能具有独立于降糖以外的抑制血小板功能的作用.
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