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The activity detection of MMP-9 and MMP-9/NGAL in urine of T2DM patients and its clinical significance
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 11
- DOI:
- 10.3969/j.issn.1006-6187.2009.11.011
- Key Word:
- 糖尿病;2型;基质金属蛋白酶9;中性粒细胞明胶酶相关脂质运载蛋白
Abstract： 目的 探讨2型糖尿病 (T2DM)患者尿液中基质金属蛋白酶9(MMP-9)及MMP-9/中性粒细胞明胶酶相关脂质运载蛋白(NGAL)的活性与T2DM的关系.方法 应用明胶酶谱法对35例健康人和142例T2DM患者的尿液进行检测.结果 (1)急性并发症组尿液中MMP-9及MMP-9/NGAL的活性及其检出率明显高于对照组及单纯糖尿病组(P<0.01);(2)慢性并发症组尿液MMP-9及MMP-9/NGAL的活性及其检出率也明显高于对照组(P<0.01),肾损害亚组MMP-9活性明显高于无肾损害亚组(P<0.05),且其活性随病程呈抛物线型变化趋势.结论 通过对MMP-9及MMP-9/NGAL活性的检测,可预测炎症、应激的发生,MMP-9及MMP-9/NGAL可作为糖尿病肾损害的早期诊断指标.
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