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Investigation of cut point of OGTT-1hPG for prediabetes and the relation of 1hPG with the function of β cell
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 9
- DOI:
- 10.3969/j.issn.1006-6187.2009.09.011
- Key Word:
- 负荷后1小时血糖;切点;胰岛β细胞功能
Abstract： 目的 探讨非糖尿病(DM)人群糖负荷后1小时血糖(1hPG)的切点及其与胰岛β细胞功能的关系. 方法 以OGTT1hPG值为8.0mmol/L和10.5mmol/L为界将非DM人群分为三组,比较各组胰岛β细胞功能和相关指标. 结果 (1)1hPG>8.0mmol/L时,HOMA-β、ΔI/ΔG、30min Ins和AUC30Ins低于1hPG<8.0mmol/L组(P＜0.05或P＜0.01),HOMA-IR高于1hPG<8.0mmol/L组(P＜0.05);(2)1hPG>10.5mmol/L时胰岛β细胞功能和相关指标改变更明显. 结论 1hPG>8.0mmol/L时有胰岛β细胞功能改变、早相胰岛素分泌减少及外周胰岛素抵抗存在,1hPG>10.5mmol/L时这些改变更明显.推测8.0mmol/L可能为1hPG的切点.
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