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Relationship of neuroD1 A45T gene polymorphism with ketosis-prone diabetes in patients without islet autoantibody
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 9
- DOI:
- 10.3969/j.issn.1006-6187.2009.09.007
- Key Word:
- 神经分化因子1;酮症倾向糖尿病;基因;多态性
Abstract： 目的 探讨NeuroD1基因A45T多态性与胰岛自身抗体阴性的酮症倾向糖尿病(KPD)的关系. 方法 应用PCR-测序法对296例GAD-Ab和IA-2Ab阴性酮症倾向糖尿病患者(KPD组)和399例非糖尿病对照者(NC组)检测了NeuroD1基因外显子2的A45T基因型,对等位基因和基因型频率进行分析. 结果 自身抗体阴性的KPD患者NeuroD1基因A45T的AA基因型频率和A等位基因频率与NC组比较差异均无显著性.对患者进行年龄和性别分层后仍未发现NeuroD1基因A45T基因型和等位基因频率与对照组有差别. 结论 在本组汉族人中,NeuroD1基因的Ala45Thr多态性与自身抗体阴性KPD无相关性.
- [1]叶林秀,徐焱成,朱宜莲,等.1型糖尿病病人神经源分化因子NeuroD/BETA2基因多态性研究[J].2003,(3).
- [2]叶林秀,徐焱成,朱宜莲,等.神经源分化因子基因多态性与2型糖尿病的关联性研究[J].2002,(6).
- [3]Nozaki O,Egashira T,Kanatsuka A.beta-cell dysfunction in late-onset diabetic subjects carrying homozygous mutation in transcription factors NeuroD1 and Pax4.[J].2002,51(9).
- [4]Lu HJ,Li M,Zheng TS,etc.Ala45Thr variation in neuroD1 gene is associated with early-onset type 2 diabetes with or without diabetic pedigree in Chinese[J].2006,290(1).
- [5]M S, German,J, Wang,R B, Chadwick,etc.Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex.[J].1992,6.
- [6]Motohashi Y,Hirose H,Saruta T,etc.NeuroD/beta2 gene G-->A polymorphism may affect onset pattern of type 1 diabetes in Japanese.[J].2001,24(8).
- [7]J B, Copeman,F, Cucca,C M, Hearne,etc.Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33.[J].1995,9.
- [8]Serup P,Heller RS,Guillemot F,etc.Control of endodermal endocrine development by Hes-1.[J].2000,24(1).
- [9]Ioannidis JP,Kavvoura FK.Ala45Thr polymorphism of the NEUROD1 gene and diabetes susceptibility: a meta-analysis.[J].2005,116(3).
- [10]F J, Naya,H P, Huang,Y, Qiu,etc.Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice.[J].1997,11.