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The diagnostic value of protein tyrosine phosphatase antibody for latent autoimmune diabetes in adults
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 9
- DOI:
- 10.3969/j.issn.1006-6187.2009.09.005
- Key Word:
- 糖尿病;2型;蛋白酪氨酸磷酸酶抗体;糖尿病;成人隐匿性自身免疫性
Abstract： 目的 探讨蛋白酪氨酸磷酸酶抗体(IA-2A)对成人隐匿性自身免疫性糖尿病(LADA)的诊断价值. 方法 采用放射配体法检测2027例初诊2型糖尿病(T2DM)患者的IA-2A和谷氨酸脱羧酶抗体(GAD-Ab),分析IA-2A在初诊T2DM患者中的分布及其与临床特征的关系. 结果 初诊T2DM患者中IA-2A阳性检出率低于GAD-Ab阳性检出率(2.2% vs 10.6%, P＜0.01).联合GAD-Ab和IA-2A检测,可使LADA阳性检出率达11.5%.IA-2A在低体重、低C肽水平患者中阳性检出率高;随着起病年龄增大,IA-2A阳性检出率下降(P＜0.05).与T2DM组比较,单独IA-2A阳性患者使用胰岛素治疗的比例高(P＜0.05).高滴度IA-2A阳性LADA患者具有起病年龄小 (P＜0.01)、体重轻、高血压比例低、空腹C肽低、合并GAD-Ab阳性和使用胰岛素比例高(P＜0.05) 等特点. 结论 IA-2A检测对LADA具有辅助诊断价值,与GAD-Ab联合检测可提高LADA诊断的敏感性.
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