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The expression and its significance of FGL2 prothrombinase in the cardiomyopathy of diabetic rats
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 8
- DOI:
- 10.3969/j.issn.1006-6187.2009.08.019
- Key Word:
- 纤维蛋白原样2凝血酶原酶;糖尿病;微血栓;微血管病变
Abstract： 目的 探讨纤维蛋白原样2(FGL2)凝血酶原酶在糖尿病大鼠心脏的表达及其意义.方法 实验大鼠随机分为对照(NC)组和2型糖尿病(T2DM)组.HE染色及纤维素染色(改良MSB染色)观察大鼠心脏病理改变,随机计数微血管中微血栓形成的阳性血管数;逆转录PCR法、免疫组织化学法测定FGL2凝血酶原酶在大鼠心脏的表达. 结果 与NC组相比, FGL2凝血酶原酶在T2DM大鼠的心脏微血管内皮细胞中高表达;T2DM组大鼠心脏微血管内可见微血栓形成;T2DM组大鼠阳性血管数显著高于NC组,且与FGL2凝血酶原酶蛋白表达呈正相关. 结论 FGL2凝血酶原酶可能通过介导糖尿病心脏微血栓形成而促进糖尿病微血管病变的发生与发展.
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