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The effects of glycemic control on levels of nuclear factor κB activity in peripheral blood mononuclear cell and on serum inflammation markers in newly diagnosed type 2 diabetics
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 8
- DOI:
- 10.3969/j.issn.1006-6187.2009.08.016
- Key Word:
- 糖尿病,2型;炎症;核因子κB;高敏C反应蛋白
Abstract： 目的 探讨血糖控制对新诊断T2DM患者外周血单核细胞(PBMNC)中核因子κB(NF-κB)活性及血清炎症指标的影响.方法 96例新诊断T2DM患者,观察治疗前及血糖良好控制后PBMNC中磷酸化NF-κBp65(Ser536)、血清炎症指标及FFA等变化. 结果 在血糖控制达标2周时,PBMNC磷酸化NF-κBp65(Ser536)、FFA及血清3项炎症指标水平比治疗前显著降低.ΔhsC-RP与Δ2hPG、Δ糖化血清蛋白(FA)呈正相关;与ΔHDL-C呈负相关;ΔIL-6与ΔTC、ΔLDL-C呈正相关(P<0.05或P<0.01). 结论 新诊断T2DM患者在严格控制血糖后,血清hsC-RP、IL-6和TNF-α水平以及PBMNC中NF-κB磷酸化p65(Ser536)水平均明显降低.血糖改善带来炎症状态的改善.
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