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Effect of AGE on insulin sensitivity and expression of SAA mRNA in 3T3-L1 adipocytes
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 8
- DOI:
- 10.3969/j.issn.1006-6187.2009.08.008
- Key Word:
- 糖基化终产物;3T3-L1脂肪细胞;葡萄糖摄取;血清淀粉样蛋白A
Abstract： 目的 探讨糖基化终产物(AGE)对3T3-L1脂肪细胞胰岛素敏感性及SAA3基因表达的影响.方法 以2-DG摄入法观察葡萄糖的摄取率,用RT-PCR检测脂肪因子SAA3 mRNA的表达. 结果 AGE显著减少3T3-L1脂肪细胞在胰岛素刺激下的葡萄糖摄取,呈剂量和时间依赖效应;AGE显著增加脂肪细胞SAA3 mRNA的表达,呈剂量依赖方式. 结论 AGE能降低3T3-L1脂肪细胞对葡萄糖的摄取,增加3T3-L1脂肪细胞对淀粉样蛋白的表达.
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