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Pioglitazone reduces serum retinol binding protein 4 and improves insulin resistance and lipid metabolism disorder
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1006-6187.2009.06.021
- Key Word:
- 吡格列酮;脂代谢;胰岛素抵抗;血清视黄醇结合蛋白4;磷酸烯醇式丙酮酸羧激酶
Abstract： 目的 探讨吡格列酮(Pio)改善胰岛素抵抗(IR)的可能机制和对血脂的影响.方法 30只Wistar雄性大鼠分为阴性对照(NC)、高脂饮食(HF)、吡格列酮(Pio)3组.采用高脂饮食对HF组及Pio组大鼠制作IR模型,成功后Pio组给予Pio 20mg·kg-1·d-1灌胃.8周后检测相应指标.结果 与HF组相比,Pio组HOMA-IR、TG、LDL-C、视黄醇结合蛋白4水平及磷酸烯醇式丙酮酸羧激酶(PEPCK)酶比活性均明显降低(P均<0.05),HDL-C明显升高(P<0.05).结论 吡格列酮能降低血清视黄醇结合蛋白4水平,抑制肝脏PEPCK酶活性,改善IR和糖、脂代谢.
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