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The relationship between FFA and type 2 diabetic nephropathy
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 6
- DOI:
- 10.3969/j.issn.1006-6187.2009.06.005
- Key Word:
- 游离脂肪酸;糖尿病肾病;胰岛素抵抗指数
Abstract： 目的 检测2型糖尿病肾病(DN)患者血清游离脂肪酸(FFA)、空腹胰岛素(FIns)及24小时尿微量白蛋白排泄量(24hMAU),探讨FFA、胰岛素抵抗指数(HOMA-IR)与DN之间的关系.方法 95例2型糖尿病患者根据24hMAU分为三组,并检测FFA、血脂、FPG、FIns、HbA1c,计算HOMA-IR.结果 (1)微量蛋白尿(MA)组及临床蛋白尿(CA)组FFA水平较正常蛋白尿(NA)组明显增高(P<0.05).(2)MA组和CA组HOMA-IR较NA组均升高,CA组有显著差异(P<0.01);CA组较MA组也显著增高(P<0.01).(3)MA组和CA组TG、TC均较NA组明显增高 (P<0.05),CA组TG较MA组明显增高(P<0.05),LDL-C较NA组明显增高(P<0.05),HDL-C较NA组明显降低(P<0.05).(4)FFA与TG、24hMAU、FIns及HOMA-IR呈显著正相关.结论 DN患者存在明显的血脂代谢异常及IR,且FFA水平与24hMAU、HOMA-IR呈正相关.
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