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Effect of rosiglitazone versus insulin on the first phase insulin secretion of islet β cell in type 2 diabetes patients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 4
- DOI:
- 10.3969/j.issn.1006-6187.2009.04.003
- Key Word:
- 糖尿病,2型;罗格列酮;胰岛素;胰岛β细胞功能;治疗
Abstract： 目的 罗格列酮(RGZ)与胰岛素治疗对2型糖尿病(T2DM)患者胰岛功能的影响. 方法 FPG>11.1mmol/L的患者随机分为胰岛素治疗(Ins)组和胰岛素+罗格列酮治疗(Ins+RGZ)组,两组年龄、病程、BMI均无统计学差异.血糖达标后再维持治疗3个月.治疗前后均作静脉糖耐量试验(IVGTT),比较两组糖代谢和胰岛功能的变化. 结果 治疗后的FPG、2hPG、HbA2c、静脉葡萄糖曲线下面积(AUC-G0～60)均显著下降,HOMA-β改善(P<0.01或P<0.05),两组问无统计学差异.两组IVGTT10min内胰岛素释放曲线下面积/60min内胰岛素释放曲线下面积(AUC-I0～16/AUC-I0～60)分别增加10%和12%(P=0.085,0.05).Ins+RGZ组I2、I5、I10及FC-P显著提高,Ins组增高无统计学意义.逐步回归分析显示,治疗后FPG和2hPG下降与负荷后胰岛素增值和血糖增值比值呈正相关(r=0.593,P=0.000;r=0.548,P=0.001),表明治疗后胰岛素处理葡萄糖能力与血糖控制程度呈正相关. 结论 罗格列酮(而不是胰岛素)能恢复第一时相胰岛素分泌.T2DM患者早期联用RGZ,有利于保护胰岛β细胞功能.
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