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Protective effects of Tongluo recipe on damaged beta-cells of rat with streptozotocin-induced diabetes WANG
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 3
- DOI:
- 10.3969/j.issn.1006-6187.2009.03.007
- Key Word:
- 通络方药;链脲佐菌素;β细胞;氧化应激
Abstract： 目的 研究通络方药(TLR)对链脲佐菌素(STZ)所致大鼠胰岛β细胞损伤的保护作用.方法 建立糖尿病大鼠模型前8天开始给予TLR直至实验结束.实验结束时测血糖、体重;取胰腺测定胰腺匀浆中丙二醛(MDA)及谷胱甘肽过氧化物酶(GSH-Px)水平,透射电镜检测胰岛β细胞.结果 与正常组相比,STZ组胰腺内MDA水平明显升高(P<0.05),GSH-Px活性明显降低(P<0.05),血糖明显升高.TLR预处理明显降低STZ组大鼠的血糖水平,同时降低大鼠胰腺匀浆内MDA含量(P<0.05),升高GSH-Px活性(P<0.05).透射电镜显示TLR预处理使胰岛β细胞的损伤明显减轻.结论 TLR通过减轻胰腺内氧化应激水平保护胰岛β细胞完整并有效防止STZ诱导的糖尿病发生.
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