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The serum adiponectin level and its correlations with markers of inflammation in patients with coronary artery disease
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 2
- DOI:
- 10.3969/j.issn.1006-6187.2009.02.007
- Key Word:
- 脂联素;冠心病;炎症;血脂
Abstract： 目的 分析冠心病患者血清脂联素(APN)水平及其与炎性相关因子的关系. 方法 经冠脉造影诊断的冠心病患者(CHD组)105例,对照(NC)组为同期住院冠脉造影正常的患者42例,两组年龄、性别、BMI相匹配.测定血清APN、肿瘤坏死因子α(TNF-α)、白介素6(IL-6)、高敏C反应蛋白(hsC-RP). 结果 (1)与NC组相比,CHD组APN、HDL-C显著降低,而TNF-α、IL-6、hsC-RP、 HOMA-IR均显著高于NC组(P均<0-01).(2)以APN为因变量、各指标为自变量进行Pearson相关分析,BMI、腰围、HOMA-IR、 hsC-RP、 IL-6、 TNF-α、TG与APN水平呈负相关,而HDL-C与APN水平正相关(P<0-01);多元逐步回归分析显示IL-6、TG、HDL-C与血清APN水平独立相关(P均<0-01). 结论 脂联素与动脉硬化相关的炎性因子及血脂密切相关,可能在冠心病发病中起了重要作用.
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