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Effect of free fatty acids on hepatic glucose production, glucose cycling and total glucose output
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 1
- DOI:
- 10.3969/j.issn.1006-6187.2009.01.021
- Key Word:
- 肝脏葡萄糖生成;总葡萄糖输出;葡萄糖循环
Abstract： 目的 探讨FFA增加肝脏葡萄糖生成和肝脏胰岛素抵抗(IR)的作用位点. 方法分别给清醒大鼠输注24h脂肪乳+肝素和盐水,在输注的最后2h行高胰岛素正葡萄糖钳夹试验,测定肝脏葡萄糖生成率(HGP)、总葡萄糖输出率(TGO)和葡萄糖循环(GC). 结果 脂肪乳使血浆FFA升高3倍.在基础状态,脂肪乳使HGP和TGO增高(P<0.01).在钳夹状态,脂肪乳降低了胰岛素(Ins)增加GC的作用(P<0.01),并使Ins抑制HGP和TGO的作用下降(P<0.01). 结论 FFA能使Ins增加GC和抑制HGP与TGO的作用下降,说明FFA在不同位点诱导了肝脏IR.
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