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Abnormality of glucose metabolism and therapeutic outcomes in patients with pituitary growth hormone-secreting adenoma: Analysis of 214 cases
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 1
- DOI:
- 10.3969/j.issn.1006-6187.2009.01.008
- Key Word:
- 垂体生长激素分泌瘤;糖尿病;临床转归
Abstract： 目的 探讨垂体生长激素分泌瘤(垂体GH瘤)患者糖代谢异常的发生率以及治疗后的转归. 方法分析1999-2008年在本院就诊的214例垂体GH瘤患者糖代谢异常情况以及治疗后的转归. 结果 垂体GH瘤患者治疗前糖代谢异常117例(54.7%),其中IFG、IGT以及DM分别为13例(6.1%)、32例(15.0%)和72例(33.6%).治疗后治愈(GH谷值≤1ng/ml)的35例DM患者中有14例(40%)转为NGT,未治愈的37例DM患者中有7例(18.9%)转为NGT,两组比较差异有统计学意义(P<0.01).未治愈的63例NGT患者中治疗后11例转为糖耐量异常.经多元回归分析,垂体GH瘤发病年龄及病程是发生DM的危险因素;治疗后DM的转归与垂体GH瘤治疗后GH是否降至正常和病程显著相关(P<0.01),与性别、年龄、血压、治疗前GH水平及肿瘤大小未见明显相关. 结论垂体GH瘤患者可出现不同程度的糖耐量异常.治疗后,GH完全恢复正常的患者,多数糖耐量异常的情况可明显改善或治愈.病程越长,垂体GH瘤患者糖耐量异常越难恢复正常.
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