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Study on the predictable markers and risk factors for early diabetic nephropathy

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
12
DOI:
10.3321/j.issn:1006-6187.2008.12.007
Key Word:
转铁蛋白;肌酐;比值;尿白蛋白;糖尿病肾病;Diabetic nephropathy

Abstract: Objective To investigate the prevalence,predictable markers and risk factors for early diabetic nephropathy(DM). Methods Urinary transferrin-to-creatinine ratio (UTRF/Cr) and urinary albumin-to-creatinine ratio (UALB/Cr) and other clinical parameters such as waist circumference,blood pressure,body mass index(BMI) and lipids were measured in 262 subjects (103 subjects with NGT,98 with IGT,61 with DM). Results 1. UTRF/Cr was positively related with UALB/Cr (r=0.618,P<0.001). 2.Both UALB/Cr(Median,range) and UTRF/Cr(Median,range) were significantly higher in IGT group than in the NGT group(0.015,0.44 mg/mg vs 0.012,0.58 mg/mg,t=-1.981,P=0.049;0.064,4.96mg/mg vs 0.034,7.30mg/mg,t=-2.249,P=0.026). 3.The positive rate of UTRF/Cr was significantly higher than that of microalbuminuria (41.6% vs 29.7%,P<0.01). 4. Logistic regression analysis showed that diastolic blood pressure (OR 1.064,95%CI 1.003-1.097,P<0.001) and 2h plasma glucose (OR 1.109,95%CI 1.032-1.191,P<0.001) were risk factors for the development of microalbuminuria in all groups,while diastolic pressure (OR 1.064,95%CI 1.028-1.101,P<0.01) was the only risk factor in nondiabetic subjects. Conclusions The prevalence of early diabetic nephropathy is high even in the stage of IGT. Hypertension is a main risk factor for the development of DN. UTRF/Cr is more sensitive than UALB/Cr for detecting diabetic nephropathy

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