The clinical significance of lowering the cut-point of impaired fasting glucose: in view of insulin sensitivity and islet β cell function
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 9
- DOI:
- 10.3321/j.issn:1006-6187.2008.09.002
- Key Word:
- 空腹血糖受损;胰岛素敏感性;胰岛β细胞功能;Islet β-cell function
Abstract： Objective To evaluate the features of insulin sensitivity and β-cell function in a Chinese population with normal fasting glucose.Methods 2,388 subjects aged≥20 years were divided into 5 groups based on the results of oral 75-g glucose tolerance test(OGTT):low-NFG,mid-NFG,high-NFG,IFG,T2DM.We compared insulin secretion and insulin sensitivity using several indexes derived from OGTT.Results There was a progressive decline in indexes of β-cell function and insulin sensitivity when moving from NFG to type 2 diabetes.Compared with subjects with mid-NFG(FPG 4.9～5.6mmol/l),subjects with high-NFG(FPG5.6～6.1mmol/l)were more resistant to insulin,and had reduced insulin secretion,higher plasma triglyceride level and reduced HDL cholesterol concentrations(P<0.01～0.001)。 Conclusion Subjects with FPG 5.6～6.1mmol/l may predispose to type 2 diabetes
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