The effect of baicalin on tissue aldose reductase activity and retinal apoptosis in diabetic rats
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 8
- DOI:
- 10.3321/j.issn:1006-6187.2008.08.020
- Key Word:
- 醛糖还原酶;细胞凋亡;糖尿病视网膜病变;醛糖还原酶抑制剂;黄芩苷;Baicalin
Abstract： Four groups included normal control (NC,n=10),diabetes mellitus without any treatment (DM,n=9),DM plus epalrestat treatment (EPS,n=10),DM plus baicalin treatment (BCL,n=10).The tissue aldose reductase activity(ARA) was higher in DM group than in NC group (P<0.01), and lower in groups of EPS or BCL treatment than in DM group (all P<0.01).The protein expressions of retinal Bcl-2 and Bax were higher in DM than in NC gruoup (all P<0.05) and lower in EPS or BCL treatment than in DM group (all P<0.01). In conclusion,ARA is increased in DM rat,which promotes the protein expression of Bax and Bcl-2 and the corresponding apoptosis of retinal cell. And ARA inhibitors epalrestat and baicalin are able to delay the development of diabetic retinopatly
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