Abstract: Serum adiponectin and adiponectin gene SNP45 were assayed by RIA and TaqMan technology respectively and analyzed in 289 patients with type 2 diabetes and in 103 normal controls. The results showed that serum adiponectin level was closely correlated with glucolipid metabolic disturbances, and SNP45 G/G genotype seemed to be the susceptible gene for pathogenesis of type 2 diabetes in Chinese Han