Association of adiponectin receptor 1(Adipo R1)gene polymorphism with type 2 diabetes
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 7
- DOI:
- 10.3321/j.issn:1006-6187.2008.07.004
- Key Word:
- 糖尿病,2型;基因;易感性;多态性,单核苷酸; Diabetes mellitus,type 2;Gene; Susceptibility; Polymorphism, single nucleotide
Abstract： Objective To study the association of SNP of the AdipoR1 gene with T2DM in Xi’an population. Methods The amplification refractory mutation system(ARMS) analysis and gene sequencing were used to investigate the AdipoR1 gene polymorphism in 100 type 2 diabetics and 84 normal control subjects. Results (1) The genotype and allele frequencies of -106A/G, 5843A/G were not significantly different between type 2 diabetics and normal control subjects. (2) The diagnosis age of diabetics was significantly younger in AdipoR1 5843GG genotype group than in other genotype groups. Conclusions The data implicate that the AdipoR1 gene -106A/G and 5843A/G polymorphism may be not associated with pathogenesis of T2DM. AdipoR1 5843 GG genotype may be associated with the earlier diagnosis of T2DM
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