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Expression and distribution of VLDLR and its subtypes in various tissues of type 2 diabetic rat

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
5
DOI:
10.3321/j.issn:1006-6187.2008.05.018
Key Word:
极低密度脂蛋白受体;基因表达;糖尿病,2型;Receptors,VLDL;Gene expression; Diabetes mellitus,type 2

Abstract: Objective To investigate the distribution and expression of total amount and two subtypes of very low density lipoprotein receptor(VLDLR)in various tissues(heart,cerebrum,kidney,muscle,adipose)of normal SD rats and type 2 diabetic SD rats.Methods The mRNA of VLDLR from various tissues were amplified by semi-quantitative RT-PCR.Results The expression levels of VLDLR were reduced in all collected tissues compared with normal ones,especially in cerebrum,kidney,muscle,adipose(P<0.01).The type I and type II VLDLR expressions were all decreased in cerebrum and kidney.In muscle,type I VLDLR expression was sharply reduced(P<0.001),but in adipose,type II VLDLR was greatly decreased(P<0.001).Conclusions The state of insulin resistant and disorder of lipid metabolism in type 2 diabetes can affect the expression and distribution of VLDLR in tissues

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