Abstract: Objective To investigate the distribution and expression of total amount and two subtypes of very low density lipoprotein receptor(VLDLR)in various tissues(heart,cerebrum,kidney,muscle,adipose)of normal SD rats and type 2 diabetic SD rats.Methods The mRNA of VLDLR from various tissues were amplified by semi-quantitative RT-PCR.Results The expression levels of VLDLR were reduced in all collected tissues compared with normal ones,especially in cerebrum,kidney,muscle,adipose(P<0.01).The type I and type II VLDLR expressions were all decreased in cerebrum and kidney.In muscle,type I VLDLR expression was sharply reduced(P<0.001),but in adipose,type II VLDLR was greatly decreased(P<0.001).Conclusions The state of insulin resistant and disorder of lipid metabolism in type 2 diabetes can affect the expression and distribution of VLDLR in tissues