Analysis of the clinical features of type 2 diabetes mellitus patients complicated with coronary heart disease

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WU Bei()
CHEN Hong()
REN Jing-yi()
Journal Title:
Volume 16, Issue 04, 2008
Key Word:

Abstract: Objective To analyze the clinical features of type 2 diabetes mellitus(DM)patients complicated with coronary heart disease(CHD).Methods 336 DM patients undergoing coronary angiography were divided into two groups:DM with CHD(n=267)and DM without CHD(n=69).General conditions,lipid profiles,glycemic control,other serum biochemical parameters and inflammatory parameters were detected and compared.And then,logistic regression analysis was used to find the independent risk factors for CHD in DM patients.Results There were several differences between DM with and without CHD in parameters including DM duration(P=0.038),smoking history(P=0.000),W/H ratio(P=0.000),HDL-C(P=0.006),FPG(P=0.000),HbA1c(P=0.000),CREA(P=0.006),hs-CRP(P=0.011),WBC(P=0.000)and NEU%(P=0.000).But only 4 parameters,including DM duration(OR=0.925),smoking history(OR=3.576),HDL-C(OR=2.839)and FPG(OR=0.819)were independent risk factors.Conclusion The DM patients who have long DM duration,smoking history,poor glycemic control and reduction of HDL-C are inclined to suffer CHD.

  • [1]纪立农.糖尿病是"冠心病的等危症"的概念及其在糖尿病心血管并发症防治中的意义.中华糖尿病杂志,2004,12:152-153.
  • [2]Fox CS,Sullivan L,D'Agostino RB Sr,et al.The significant effect of diabetes duration on coronary heart disease mortality:the Framingham Heart Study.Diabetes Care,2004,27:704-708.
  • [3]Drexel H,Langer P,Aczel S,et al.Is atherosclerosis in diabetes and impaired fasting glucose driven by elevated LDL cholesterol or by decreased HDL cholesterol? Diabetes care,2005,28:108-114.
  • [4]Smaoui M,Hammami S,Chaaba R,et al.Lipids and lipoprotein(a) concentrations inTunisian type 2 diabetic patients Relationship to glycemic control and coronary heart disease.Journal of Diabetes and Its Complications,2004,18:258-263.
  • [5]Olsson AG,Schwartz GG,Szarek M,et al.High-density lipoprotein,but not low-density lipoprotein cholesterol levels influence short-term prognosis after acute coronary syndrome:results from the MIRACL trial.European Heart Journal,2005,26:890-896.
  • [6]Richard J S,Viti Kothari,Amanda I A,et al.The UKPDS risk engine:a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56).Clinical Science,2001,101:671-679.
  • [7]Liu Y,Terata K,Rusch N,et al.High Glucose Impairs Voltage-Gated K1 Channel Current in Rat Small Coronary Arteries.Circculation Research,2001,89:146-152.
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