Study of correlations of ABCA1 R219K gene polymorphism with coronary heart disease in subjects with type 2 diabetes

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Author:
LIU Jing()
GAO Qing-ge()
ZHAN Li()
()
()
()
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
Volume 16, Issue 02, 2008
DOI:
Key Word:

Abstract: Objective To investigate the relationship of the polymorphism of ATP-binding cassette transporter 1(ABCA1) R219K with coronary heart disease(CHD) in Chinese Han type 2 diabetic patients. Methods 83 normal subjects and 143 T2DM patients [71 combined with CHD (CHD+),72 without CHD(CHD-)]were enrolled in this study.The genotype and allele frequencies of ABCA1 R219K genetic variation were assayed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results Groups of NC,CHD-and CHD+ showed that frequencies of KK genotype were 19.3%,16.7%,4.2% separately,and the frequencies of K allele were 42.2%,38.9%,31.7% separately.The genotypes in the CHD+ group were significantly different from the NC and CHD-groups (χ2=7.441,P=0.024;χ2=9.453,P=0.009).The KK genotype had a significantly higher HDL-C level than RR and RK genotypes(all P<0.05). Conclusions The ABCA1 R219K gene polymorphism may be correlated to CHD.

  • [1]Srivastava N.ATP-binding cassette transporter A1-key roles in cellular lipid transport and atherosclerosis.Mol Cell Biochem,2002,237:155-164.
  • [2]Oram JF,Lawn RM.ABCA1:The gatekeeper for eliminating excess tissue cholesterol.J Lipid Res,2001,42:1173-1179.
  • [3]Santa marina,Fojo S,Pterson K,Knapper C,et al.Complete genomic sequence of the human ABCA1 gene 1:analysis of the human and mouse ATP-blinding cassatte A promoter.Proc Natl Acad Sci USA,2000.97:7981-7992.
  • [4]Clee SM,Zwinderman AH,Engert JC,et al.Common genetic、variafion in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease,Circulation,2001,103:1198-1205.
  • [5]赵水平,肖志杰,李全忠,等.冠心病患者ATP结合盒转运子A1基因R219K变异的研究.中华心血管病杂志,2004,32:712-716.
  • [6]Frikke-Schmidt R,Nordestgaard BG,Jensem GB,et al.Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population.J Clin Invest,2003,114:1343-1353.
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