The study on the mRNA expressions of adiponectin and tumor necrosis factor alphal and on their relation with insulin resistance in omental adipose tissue of obese subjects

( views:77, downloads:0 )
CHEN Ming-wei()
SHI Zhao-ming()
HE Heng-jie()
Journal Title:
Volume 16, Issue 01, 2008
Key Word:

Abstract: The study of omental adipose tissue of patients with obesity(n=19)and without obesity(n=24)showed that the expression of adiponectin(APN)gene was significantly lower in obesity subjects than in non-obesity subjects and the expression of TNF-α gene was significantly higher in obesity than in non-obesity.There was negative correlation between the expressions of APN and TNF-α gene in obesity subjects.The obesity and insulin resistance were the independent influencing factors for the expressions of APN and TNF-α gene.

  • [1]陈明卫,王佑民,胡红琳,等.血清肿瘤坏死因子α、游离脂肪酸以及抵抗素与2型糖尿病患者胰岛素抵抗的关系.中国糖尿病杂志,2006,14:4-6.
  • [2]Mishima Y,Kuyama A,Tada A,etal.Relationship between serum tumor necrosis factor-alpha and insulin resistance in obese men with type 2 diabetes mellitus.Diabetes Res Clin Pract,2001,52:119-123.
  • [3]Kern PA,Di Gregorio GB,Lu T,etal.Adiponectin expression from human adipose tissue relation to obesity,insulin resistance,and tumor necrosis factor-α expression.Diabetes,2003,52:1779-1785.
  • [4]Bruun JM,Lihn AS,Verdich C,etal.Regulation of adiponectin by adipose tissue-derived cytokines:in vivo and in vitro investigations in humans.Am J Physiol Endocrinol Metab,2003,285:E527-E533.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615