You Position: Home > Paper
Efficacy of extended-release metformin and its effects on pancreatic islet function and insulin resistance in type 2 diabetic patients
( views:298, downloads:200 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 12
- DOI:
- 10.3321/j.issn:1006-6187.2007.12.003
- Key Word:
- 二甲双胍缓释片;胰岛素抵抗;胰岛功能
Abstract： 目的 比较二甲双胍缓释片 (卜可) 与速释片(格华止) 对血糖、胰岛素敏感性及胰岛β细胞功能的影响.方法 多中心随机对照设计.150例2型糖尿病患者经2～3周格华止导入期后随机分为格华止组和卜可组,每组75例.格华止500mg每日3次、卜可1500mg晚餐后服用,共12周.结果 12周后,格华止或卜可均能显著降低糖尿病患者的BMI和HbA1c,卜可组标准餐后120 min血糖显著高于格华止组 (11.0±3.1mmol/L vs 7.4±2.6mmol/L,P＜0.05);两组患者胰岛素曲线下面积 (AUCIns)、胰岛β细胞功能指数和胰岛素抵抗指数均有降低趋势,但组间或组内无统计学差异.结论 卜可的降糖效能以及对2型糖尿病患者胰岛素抵抗和胰岛素分泌功能的影响与相同剂量的格华止基本相似.
- [1]Timmins P,Marathe P,Meeker J,etc.Steady-state pharmacokinetics of a novel extended-release metformin formulation.[J].2005,44(7).
- [2]D R, Matthews,J P, Hosker,A S, Rudenski,etc.Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.[J].1985,28.
- [3]Del Guerra S,Bugliani M,Del Prato S,etc.Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin.[J].2004,89(11).
- [4]Wagner OF,Tura A,Hanusch Enserer U,etc.Insulin sensitivity during oral glucose tolerance test and its relations to parameters of glucose metabolism and endothelial function in type 2 diabetic subjects under metformin and thiazolidinedione.[J].2006,8(5).
- [5]N. Vidon,S. Chaussade,M. Noel,etc.Metformin in the digestive tract[J].1988,4(3).
- [6]Piro S,Purrello F,Anello M,etc.Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells.[J].2000,49(5).
- [7]Joyal S,Pans M,Fujioka K.Glycemic control in patients with type 2 diabetes mellitus switched from twice-daily immediate-release metformin to a once-daily extended-release formulation.[J].2003,25(2).