You Position: Home > Paper
Hyperglycemia and endothelial dysfunction
( views:247, downloads:64 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 12
- DOI:
- 10.3321/j.issn:1006-6187.2007.12.001
- Key Word:
- 高血糖;内皮,血管;功能异常
Abstract： 糖尿病(DM)患者,甚至在DM前期即存在血管内皮细胞(EC)功能异常.EC功能异常可致DM大、微血管病变.高血糖是引起EC功能异常的重要原因之一,其机制与氧化应激有关.控制血糖、抗氧化应激及胰岛素增敏治疗可改善EC功能.
- [1]向光大,韩芳,赵林双,等.维生素C对2型糖尿病患者血管内皮功能的影响[J].2006,(10).
- [2]向光大.胰岛素抵抗与血管内皮功能[J].2005,(5).
- [3]向光大,曹红燕,曾尟枚,等.1型糖尿病患者胰岛素治疗前后内皮依赖性血管舒张功能的变化[J].2006,(2).
- [4]Isabella, Schmoelzer,Thomas C, Wascher.Effect of repaglinide on endothelial dysfunction during a glucose tolerance test in subjects with impaired glucose tolerance.[J].2006,5.
- [5]Hiroaki Kawano,Takeshi Motoyama,Osamu Hirashima,etc.Hyperglycemia rapidly suppresses flow-mediated endothelium- dependent vasodilation of brachial artery[J].1999,34(1).
- [6]Lim SC,Veves A,Smakowski P,etc.Soluble intercellular adhesion molecule, vascular cell adhesion molecule, and impaired microvascular reactivity are early markers of vasculopathy in type 2 diabetic individuals without microalbuminuria.[J].1999,22(11).
- [7]Varricchio G,Barbieri M,Gambardella A,etc.Chronic vitamin E administration improves brachial reactivity and increases intracellular magnesium concentration in type II diabetic patients.[J].2000,85(1).
- [8]Cipolla M,Calles-Escandon J.Diabetes and endothelial dysfunction: a clinical perspective.[J].2001,22(1).
- [9]Ujhelyi MR,Hoenig M,Miller AW,etc.Metformin improves vascular function in insulin-resistant rats.[J].2000,35(1 Pt.1).
- [10]Stehouwer, C.D.A.,Nauta, J.J.P..Urinary albumin excretion, cardiovascular disease, and endothelial dysfunction in non-insulin...[J].1992,340(8815).
- [11]Chou E,Takahara N,Rhodes CJ,etc.Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.[J].2000,49(7).