You Position: Home > Paper
Sibling recurrence-risk ratio analysis of early-onset type 2 diabetes family
( views:222, downloads:68 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 11
- DOI:
- 10.3321/j.issn:1006-6187.2007.11.006
- Key Word:
- λs;糖尿病,2型;早发糖尿病;患病率;家族聚集性
Abstract： 目的 通过计算早发2型糖尿病(T2DM)家系先证者同胞中糖尿病患病危险性(λs值)来评价早发2型糖尿病家系糖尿病的遗传强度.方法 :采用在1997-2004年间收集的有完整资料的北京地区227个同胞对糖尿病家系,分为早发糖尿病家系(患病司胞的诊断年龄均≤45岁)122家,晚发糖尿病家系(患病同胞的诊断年龄均＞45岁)76家.采用问卷调查的方法收集家系成员有关糖尿病信息,计算λs值.结果 总家系中λs=10.33,早发糖尿病家系λs值高于晚发糖尿病家系(P=0.000).早发糖尿病家系中糖尿病家族史比例显著高于晚发糖尿病家系(P=0.000).母系家族史比例显著高于父系家族史比例(P=0.01),但母系遗传和父系遗传家系的λs间差异无统计学意义.结论 采用患病同胞策略所收集的糖尿病家系均具有较强遗传倾向,但早发糖尿病患者同胞具有更高的糖尿病风险,早发糖尿病家系具有更强遗传倾向,选择早发糖尿病家系可能更适于寻找新的糖尿病易感基因.
- [1]李立明,饶克勤,孔灵芝,等.中国居民2002年营养与健康状况调查[J].2005,(7).
- [2]Eduardo, García-García,Carlos A, Aguilar-Salinas,Teresa, Tusié-Luna,etc.Early-onset type 2 diabetes in Mexico.[J].2002,4.
- [3]M. Viswanathan,M.I. McCarthy,C. Snehalatha,etc.Familial Aggregation of Type 2 (Non-insulin-dependent) Diabetes Mellitus in South India; Absence of Excess Maternal Transmission[J].1996,13(3).
- [4]A. Lev-Ran,E. Sprecher,Y. Yerushalmy,etc.Homogeneity of the age at diagnosis in sibs with type 2 diabetes: Implications for sib-pair analysis[J].2000,91(2).
- [5]McCarthy, Mark I.,Kruglyak, Leonid,Lander, Eric S..Sib-pair collection strategies for complex diseases[J].1998,15(4).
- [6]Thomas F.,Balkau B.,Vauzelle-Kervroedan F.,etc.Maternal Effect and Familial Aggregation in NIDDM: The CODIAB Study[J].1994.
- [7]Sun-Wei Guo.Inflation of Sibling Recurrence-Risk Ratio, Due to Ascertainment Bias and/or Overreporting[J].1998,63(1).
- [8]N J, Risch.Searching for genetic determinants in the new millennium.[J].2000,405(6788).