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The relationship of the adiponectin + 45 nucleotide T/G polymorphism with insulin resistance, obesity and type 2 diabetes

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
10
DOI:
10.3321/j.issn:1006-6187.2007.10.004
Key Word:
脂联素;多态性,糖尿病,2型;胰岛素抵抗;肥胖

Abstract: 目的 探讨宁夏汉族人群脂联素基因+45位核苷酸T/G多态性与肥胖、胰岛素抵抗(IR)及2型糖尿病(T2DM)的相关性.方法 采用聚合酶链式反应一限制性内切酶长度多态性技术,对100例T2DM患者和101例正常对照(NC)者脂联素基因+45位点进行基因分型;并计算BMI和HOMA-IR.结果 (1)T2DM组GG基因型频率明显高于NC组(P<0.01),G等位基因频率明显高于NC组(P<0.01).(2)在T2DM组中,GG+TG基因型的BMI、HOMA-IR大于TT基因型(P<0.01).在NC组中,各基因型间BMI、HOMA-IR的差异无统计学意义.在T2DM组中,而BMI≥25组的GG+TG基因型频率高于BMI<25组(P<0.01),G等位基因频率也高于BMI<25组(P<0.01).结论 脂联素基因+45位核苷酸T/G多态性与肥胖、IR及T2DM相关.

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