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Pioglitazone improves endothelial function in metabolic syndrome patients with impaired glucose tolerance
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 9
- DOI:
- 10.3321/j.issn:1006-6187.2007.09.008
- Key Word:
- 噻唑烷二酮;糖耐量减低;代谢综合征;内皮细胞功能
Abstract： 目的 研究吡格列酮(PIO)对伴糖耐量减低(IGT)的代谢综合征(MS)患者血管内皮细胞功能的影响.方法 对22例伴IGT的MS患者用PIO30mg/d治疗4个月.治疗前后测定外周组织葡萄糖摄取率(GDR)、胰岛素敏感指数(ISI)、内皮依赖性血管舒张功能(EDVD),并监测血丙二醛(MDA)、还原型谷胱甘肽(GSH)、高敏C反应蛋白(hsC-RP)、血糖、Ins、HbA1c和FFA水平的改变.结果 治疗后EDVD明显改善、GDR增加(P均＜0.01),ISI升高(P均＜0.05).血糖、Ins、HbA1c、FFA、MDA及hsC-RP水平降低(P均＜0.01),GSH水平升高(P＞0.05).结论 短期PIO治疗能使伴IGT的MS患者的内皮细胞功能明显改善,其机制可能与缓解内皮细胞胰岛素抵抗以及氧化应激和慢性炎症状态有关.
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