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The LADA variations in the clinical, β cell function and immunologic characteristics with advancement of the course of disease
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 9
- DOI:
- 10.3321/j.issn:1006-6187.2007.09.005
- Key Word:
- 糖尿病;成人隐匿性自身免疫性糖尿病
Abstract： 目的 探讨成人隐匿性自身免疫性糖尿病(LADA)患者病情随病程进展的变化情况.方法 从300例2型糖尿病患者中筛选出LADA 28例,进行5年前后的临床、胰岛功能及免疫学比较研究.结果 28例LADA患者5年后病情加重,胰岛功能减退直至衰竭,谷氨酸脱羧酶抗体(GAD-Ab)持续阳性的患者β细胞功能呈进行性减退.结论 LADA患者随病程延长其胰岛β细胞功能呈进行性减退直至衰竭而必须依赖胰岛素治疗;GAD-Ab持续阳性的患者β细胞功能呈进行性减退.
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