You Position: Home > Paper
The diagnostic values of IA-2Ab,GAD-Ab AND IAA in distinguishing between type 1 and 2 diabetes mellitus
( views:514, downloads:120 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 9
- DOI:
- 10.3321/j.issn:1006-6187.2007.09.004
- Key Word:
- 酪氨酸磷酸酶抗体;谷氨酸脱羧酶抗体;胰岛素自身抗体;糖尿病
Abstract： 对46例1型糖尿病(T1DM)患者、48例2型糖尿病(T2DM)患者,50例T1DM患者非糖尿病一级亲属(N-DMFR)及46例健康志愿者(NC)的酪氨酸磷羧酶抗体(IA-2Ab)、谷氨酸脱羧酶抗体(GAD-Ab)和胰岛素自身抗体(IAA)以及FPG、2hPG、HbA1c、胰岛素、C肽.结果IA-2Ab阳性者T1DM组为47.8%、N-DMFR组为28%,明显高于NC组(P＜0.05);GAD-Ab阳性者T1DM组71.7%、N-DMFR组24%,明显高于NC组(P＜0.05);IAA阳性者为T1DM组65.2%、T2DM组8.3%、N-DMFR组4.0%、NC组无阳性者.两种或两种以上抗体阳性者T1DM组63.0%,N-DMFR组6%;T2DM及NC组无检出者.IA-2Ab、GAD-Ab、IAA的联合检出有利于糖尿病的预测、早期诊断及正确分型.
- [1]杨琳,周智广,黄干,等.四种胰岛自身抗体诊断成人隐匿性自身免疫性糖尿病的临床意义[J].2005,(4).
- [2]王建平,周智广,黄干,等.IA-2A与GADA检测对1型糖尿病的诊断价值[J].2004,(6).
- [3]李霞,周智广.谷氨酸脱羧酶抗体滴度与成人隐匿性自身免疫糖尿病[J].2005,(2).
- [4]Hawa MI,Medici F,Deng YJ,etc.Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: isotype restriction and polyclonality (see comments)[J].2000,23(2).
- [5]C F, Verge,R, Gianani,E, Kawasaki,etc.Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies.[J].1996,45.