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Overexpression of tyrosine protein phosphatase 1B in adipose tissues of newly diagnosed metabolic syndrome patients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 6
- DOI:
- 10.3321/j.issn:1006-6187.2007.06.001
- Key Word:
- 蛋白酪氨酸磷酸酶1B;代谢综合征;脂肪组织
Abstract： 目的 研究蛋白酪氨酸磷酸酶1B(PTP-1B)在代谢综合征(MS)发病中的作用.方法 51例患者分为对照(NC)组、2型糖尿病(T2DM)组和MS组,测定FPG、Fins,Western印迹法测定内脏脂肪组织PTP-1B表达水平.结果 与NC组相比,T2DM组和MS组FPG、Ln(HOMA-IR)和PTP-1B表达水平明显升高.与T2DM组相比,MS组腰围和PTP-1B显著升高.校正年龄后PTP-1B与FPG、Ln(HOMA-IR)、腰围(WC)和SBP均呈正相关.结论 内脏脂肪组织PTP-1B表达升高与肥胖、糖代谢紊乱等MS危险因素明显相关,可见内脏脂肪组织PTP-1B表达异常与MS发生发展关系密切.
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