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Relationship between angiotensin converting enzyme gene polymorphism and diabetes mellitus
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 4
- DOI:
- 10.3321/j.issn:1006-6187.2007.04.010
- Key Word:
- 糖尿病,1型;糖尿病,2型;受体,骨化三醇;多肽性,限制性片段长度
Abstract： 目的 研究维生素D受体(VDR)基因BsmⅠ酶切位点多态性是否与糖尿病(DM)的易感性相关.方法 采用PCR-RFLP方法分型并用X2检验比较各组间基因型及等位基因频率的分布.结果 全部研究对象中共见BB、bb、Bb三种基因型.1型糖尿病(T1DM)BB基因型频率为2%,Bb基因型频率为47%,分别明显高于对照组的0.5%和9.2%,而2型糖尿病(T2DM)的BB基因型频率为0.6%,Bb基因型频率为10.8%,与对照组分别相似.结论 VDR基因BsmI位点多态性与T2DM的易感性可能无关(P＞0.05),但与T1DM的易感性密切相关(P＜0.05).
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