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Effects of Astragalus Polysaccharides on the expressions of MMP-2 and MMP-9 in human dermal fibroblasts from diabetic foot ulcer transudate
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 4
- DOI:
- 10.3321/j.issn:1006-6187.2007.04.004
- Key Word:
- 糖尿病足部溃疡;成纤维细胞;白介素-1β;基质金属蛋白酶
Abstract： 糖尿病足溃疡渗出液中的IL-1p显著高于急性伤口,50μg/L IL-1β显著增加足溃疡渗出液中成纤维细胞MMP-2、MMP-9的活性及其蛋白表达,100 mg/L黄芪多糖可降低MMP-2、MMP-9活性及其蛋白的表达,也可降低50μg/L IL-1p所致的MMP-2、MMP-9高活性及其蛋白高表达.
- [1]李光善,李萍,盛巡,等.黄芪多糖、桂皮醛、川芎嗪对实验性糖尿病大鼠创面成纤维细胞增殖作用的影响[J].2004,(4).
- [2]肖正华,陈定宇,周倩,等.黄芪注射液加胰岛素混合液外敷治疗糖尿病足部溃疡69例逆疗效观察[J].2005,(6).
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