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Relationship of serum level of IGFBP-1 with insulin resistance in type 2 diabetics with hypertriglyceridemia
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 3
- DOI:
- 10.3321/j.issn:1006-6187.2007.03.005
- Key Word:
- 高甘油三酯血症;胰岛素样生长因子结合蛋白质1;胰岛素抵抗
Abstract： 目的 探讨糖、脂代谢不同人群的血清胰岛素样生长因子结合蛋白1(IGFBP-1)水平与胰岛素抵抗(IR)的关系. 方法 选取正常人(NC)、高TG血症患者、2型糖尿病(T2DM)患者及T2DM+高TG患者共66例,测定血清IGFBP-1、胰岛素、血糖和血脂水平. 结果 (1)血清IGFBP-1水平,高TG血症组较NC组、T2DM+高TG组较T2DM组均明显下降(P＜0.05).(2)多元逐步回归分析显示血清IGFBP-1水平与TG、HOMA-IR负相关(P＜0.05),与HDL-C正相关(P＜0.05). 结论 高TG血症人群血清IGFBP-1明显下降,提示存在明显肝脏IR.
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