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Quantitative study of Tom-1 mRNA expression in omental adipose tissue of patients with type 2 diabetes and insulin resistance
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 3
- DOI:
- 10.3321/j.issn:1006-6187.2007.03.004
- Key Word:
- 胰岛素抵抗;脂肪组织;Tom-1基因
Abstract： 目的 探讨Tom-1基因在2型糖尿病胰岛素抵抗(T2DM-IR)患者网膜脂肪组织表达水平. 方法 取T2DM-IR患者与非糖尿病无IR者(对照组)网膜脂肪组织,用荧光定量RT-PCR技术测定Tom-1 mRNA的表达量. 结果 Tom-1 mRNA的表达量在T2DM-IR组为4440±617拷贝/百万看家基因,对照组为1360±82拷贝/百万看家基因,两者比较差异有统计学意义(P＜0.05). 结论 在人腹腔网膜脂肪组织中Tom-1 mRNA有表达,在T2DM-IR组呈上调表达.因此,这条基因可能与T2DM的IR有关.
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