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Study on the effect of controlling hypertriglyceridemia on islet β cell function and glucose metabolism
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 3
- DOI:
- 10.3321/j.issn:1006-6187.2007.03.002
- Key Word:
- 高甘油三酯血症;游离脂肪酸;胰岛β细胞;糖代谢
Abstract： 探讨控制高甘油三酯(TG)血症对胰岛β细胞分泌功能和糖代谢的影响.方法 (1)140例糖代谢异常者分为糖耐量减低(IGT)组、2型糖尿病胰岛素分泌增加(T2DM-1)组和胰岛素分泌减少(T2DM-2)组,计算胰岛素抵抗指数(HOMA-IR)和分泌指数(HOMA-β).(2)对IGT组和糖尿病组行调脂治疗;观察治疗前、后的变化.结果 (1)经调脂治疗后,IGT组FFA、空腹真胰岛素(FTI)、FPG及HOMA-IR低于治疗前,HOMA-β高于治疗前.(2)与单纯降糖比较,DM患者经过降糖调脂治疗后,T2DM-1、T2DM-2组FFA、FPG、HOMA-IR及T2DM-1组FTI含量降低,T2DM-1、T2DM-2组HOMA-β及T2DM-2组FTI含量升高.结论 积极控制高TG血症有助于降低胰岛素抵抗和改善β细胞分泌功能,纠正糖代谢紊乱.
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