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Study on the correlation of the A2518G polymorphism of MCP-1 gene and diabetic nephropathy in type 2 diabetic subjects
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 2
- DOI:
- 10.3321/j.issn:1006-6187.2007.02.009
- Key Word:
- 糖尿病肾病;单核细胞化学吸引蛋白质1;基因;多态性
Abstract： 目的 探讨单核细胞趋化蛋白(MCP-1)基因调节区A2518G多态性与湖南汉族人2型糖尿病(T2DM)合并肾病之间的关系.方法 运用聚合酶链反应限制性片段长度多态性技术(PCR RFLP),结合DNA测序技术,检测了单纯糖尿病(DM)组86例,糖尿病肾病(DN)组94例;正常对照(NC)102例,282例湖南汉族人的MCP-1基因调节区A2518G多态性.结果 DN组MCP-1 G/G基因型频率和G等位基因频率高于DM组、NC组,但差异无统计学意义(P＞0.05).结论 (1)糖代谢紊乱和脂代谢紊乱是DN发生发展的危险因素;(2)MCP-1 A2518G多态性与DN发病无相关性.
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