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The 7-years follow up of only OGTT 1 h-hyperglycemia and its transforming results in the male elderly

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
6
DOI:
10.3321/j.issn:1006-6187.2006.06.017
Key Word:
口服糖耐量试验;高血糖;临床特征;转归;Transformation

Abstract: Objective To investigate the clinical features and transformation of OGTT 1 hour hyperglycemia(≥11.1 mmol/L) only(OGTT-1 hHG) in the elderly male patients who were in normal blood glucose at fasting and 2 hours in oral glucose tolerance test(OGTT).Methods During 7 years of follow-up of the 189 elderly male outpatients with OGTT-1 hHG,the patients took OGTT every 1~2 years,and continuous records on their BMI,blood pressure,serum cholesterol and triglyceride and correlative illness history. Results Follow-up visits revealed that 19 patients with OGTT-1 hHG were diagnosed as diabetes(10.1%),78 patients as impaired glucose tolerance(IGT,41.3%),2 patients transformed to normal glucose tolerance(NGT,1.1%) and the rest 90 patients(47.6%) were unchanged as OGTT-1 hHG.Synchronized comparison with IGT patients showed that the ratio of OGTT-1 hHG patients turning to diabetes was lower than that of IGT patients(21.1%,χ~2=13.05,P<0.01),and the ratio of OGTT-1 hHG patients transforming to NGT was slightly higher(0.4%,χ~2=2.46,P>0.05).The prevalences of hypertension,coronary heart disease,cerebral vascular disease and dislipidemia in patients with OGTT-1 hHG were higher than those with NGT(P<0.05),and same as IGT. Conclusions As a special phenotype at OGTT and as part of abnormal glucose tolerance conformation,patients with OGTT-1 hHG warrant a special attention because about half of them will develop diabetes or IGT,and possess more risk agents of vascular diseases.

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