Abstract: The study of NGT with (NGT-Y, n=69) and without (NGT-N, n=56) long term smoking, IGT with (IGT-Y, n=96) and without (IGT-N, n=72) long-term smoking showed that there was no significant difference in BMI between NGT-N and IGT-Y. And there were significant differences in insulin action index, IR, and insulin secretion index between NGT-Y and IGT-Y. In conclusions, long-term smoking results in insulin resistance and the invalid insulin secretion in NGT and IGT.