Abstract： Objective To study the relationship of the levels of serum adiponectin, TNF-α,IL-6 and C-RP with insulin resistance in nondiabetic first-degree relatives ( FDR) of type 2 diabetics. Methods 82 normal glucose tolerance subjects, including 36 nondiabetic FDR of type 2 diabetes, and 46 normal control(NC) without type 2 diabetes family history were enrolled. The levels of blood glucose, lipid, insulin, adiponectin, TNF-α, IL-6 and hsC-RP were measured. Results ①Compared with NC, the levels of adiponectin in FDR were significantly decreased(11.9±3.0 mg/L vs 14.4±3.2 mg/L,P<0.01),but the levels of TNF-α, IL-6 and hsC-RP were significantly increased(14.0±2.8 pg/ml vs 10.3±2.6 pg/ml,P<0.01;13.8±2.7 pg/ml vs 8.1±2.2 pg/ml,P<0.01;1.3±0.4 mg/L vs 0.7±0.3 mg/L,P<0.01); ②In FDR, HOMA-IR was negatively correlated with adiponectin(r=-0.666,P<0.01), and positively related to TNF-α and IL-6(r=0.731,P<0.01;r=0.640,P<0.01). Conclusions Adiponectin, TNF-α,IL-6 and C-RP may correlate with the degree of insulin resistance in nondiabetic FDR of type 2 diabetics.