The relationship between T-786 →C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and type 2 diabetes with coronary heart disease
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DIABETES
- Issue:
- 1
- DOI:
- 10.3321/j.issn:1006-6187.2006.01.007
- Key Word:
- 内皮一氧化氮合酶;T-786→C突变;糖尿病,2型;冠状动脉心脏病;Endothelial nitric oxide synthase;T-786→C mutation; Diabetes mellitus,type 2; Coronary heart disease
Abstract： Objective To study the relationship between T-786→C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene and type 2 diabetes（T2DM） with coronary heart disease（CHD）. Methods One hundred and eighty-six T2DM were selected,and of them,65 had CHD.Meanwhile,63 healthy individuals were selected as control.PCR/ASO（allele-specific oligonucleotide probe） technique was used to determine the T-786→C mutation.Results Compared with control,the T/C genotype and C allele prevalences were significantly higher in T2DM with CHD（P<0.05）.Compared with T2DM without CHD,the C allele prevalence was significantly higher in T2DM with CHD（P<0.05）.Compared with T/T genotype group,the HbA1c level of T2DM was significantly higher in T/C genotype group（P<0.05）.By multiple logistic regression analysis,age,blood pressure,duration of diabetes,LDL-C,Lp（a）,HbA1c,C allele were associated with CHD development in T2DM（P<0.01）.Conclusions T-786→C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene increases the risk for CHD development in T2DM.
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