Effect of multifactorial intervention on subclinical atherosclerosis in newly diagnosed type 2 diabetes

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Author:
CHEN Xiao-yan()
ZHOU Zhi-guang()
LIU Ming-hui()
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Journal Title:
CHINESE JOURNAL OF DIABETES
Issue:
Volume 14, Issue 01, 2006
DOI:
Key Word:

Abstract: Objective To investigate the effect of primary prevention on atherosclerosis(AS) in newly diagnosed type 2 diabetics.Methods One hundred and sixty-one diabetic patients(duration ≤ 1 year) without AS was designed to undergo the targeted intervention,including the controlling of blood glucose,blood pressure,blood lipid and body weight,and taking aspirin as well.The relationship was(evaluated) after one year treatment between the status of metabolic control and the intima-media thickness(IMT) or AS plaques of common carotid artery(CCA) and femoral artery(FA),respectively.Risk factors of the subclinical AS were estimated by logistic regression analysis.Results In the whole group,CCA-IMT and FA-IMT were significantly less than baseline [(△CCA-IMT:0.08 mm,95% CI:0.06~0.11,P<0.001.△FA-IMT:0.07 mm,95% CI:0.05~0.10),P<0.001],and subclinical AS was found in 25 patients(15.5%).Logistic regression analysis showed that the risk factors related with subclinical AS were sBP targeted value [Exp(B):20.879,95% CI:3.387~128.721,P=0.001],LDL-C targeted value [Exp(B):8.047,95% CI:1.706~37.96,P=0.008] and the number of metabolic parameter control [Exp(B):2.07,95% CI:1.044~4.103,P=0.037]. Conclusions ① CCA-IMT and FA-IMT could be reversed in newly diagnosed type 2 diabetes during one-year multifactorial targeted intervention. ② The status of systolic blood pressure and low-density lipoprotein cholesterol control and the number of metabolic parameter control were the key risk factors for subclinical AS in these patients.

  • [1]Kuller LH,Velentgas P,Barzilay J,et al.Diabetes mellitus:subclinical cardiovascular disease and risk of incident cardiovascular disease and all-cause mortality.Arterioscler Thromb Vasc Bio,2000,20:823-829.
  • [2]Chambless LE,Folsom AR,Davis V,et al.Risk factors for progression of common carotid atherosclerosis:the atherosclerosis risk in communities study,1987-1998.Am J Epidemiol,2002,155:38-47.
  • [3]Yamasaki Y,Kokama M,Nishizawa H,et al.Carotid intimamedia thickness in Japanese type 2 diabetic subjects:predictors of progression and relationship with incident coronary heart disease.Diabetes Care,2000,23:1310-1315.
  • [4]Matsumoto K,Sera Y,Nakamura H,et al.Correlation between common carotid arterial wall thickness and ischemic stroke in patients with type 2 diabetes mellitus.Metabolism,2002,51:244-247.
  • [5]Temelkova-kurktschiev TS,Koehler C,Leonhardt W,et al.Increased intimal-medial thickness in newly detected type 2 diabetes:risk fartors.Diabetes Care,1999,22:333-338.
  • [6]陈小燕,周智广,傅朝,等.新发2型糖尿病患者亚临床动脉硬化的超声检查及其危险因素分析.中华老年医学杂志,2004,23:528-531.
  • [7]Goff DC,Wagenknecht LE,D'Agostino RB,et al.Lipoprotein concentrations and carotid atherosclerosis by diabetes status:results from the insulin resistance atherosclerosis study.Diabetes Care,2000,23:1006-1011.
  • [8]Gaede P,Vedel P,Larsen N,et al.Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes.N Engl J Med,2003,348:383-393.
  • [9]陈小燕,周智广,唐炜立,等.多因素干预对新诊断2型糖尿病患者代谢综合征的影响.中华糖尿病杂志,2004,12:159-163.
  • [10]Yamasaki Y,Kodama M,Nishizawa H,et al.Carotid intimamedia thickness in Japanese type 2 diabetic subjects:predictors of progression and relationship with incident coronary heart disease.Diabetes Care,2000,23:1310-1315.
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