Changes of islet β-cell function in subjects with impaired glucose tolerance

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YE Shan-dong()
ZHAO Yong-li()
KANG Dong-mei()
Journal Title:
Volume 14, Issue 01, 2006
Key Word:

Abstract: Proinsulin(PI)_(AUC) increased,and insulin action index,HOMA-β and △I_(30)/△G_(30) decreased progressively from NGT(n=131) to IGT(n=120) to T2DM(n=107).Obese group had higher HOMAβ,Ins_(AUC),C-P_(AUC) and PI_(AUC) than did the non-obese group.

  • [1]叶山东,程桦.糖耐量减退的研究进展.国外医学内科学分册,2002,29:385-397.
  • [2]李光伟.胰岛β细胞功能评估.国外医学内分泌学分册,2003,23:159-163.
  • [3]Stumvoll M,Mitrakou A,Pimenta W,et al.Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity.Diabetes Care,2000,23:295-301.
  • [4]Garber AJ.The importance of early insulin secretion and its impact on glycaemic regulation.Int J Obes Metab Disord,2000,24:s32-37.
  • [5]Homo-Delarche F.Beta-cell behavior during the prediabetic stage.Part Ⅰ.Beta-cell pathophysiology.Diabetes Metab,1997,23:181-194.
  • [6]Vauhkonen L,Niskanen L,Vannien E,et al.Defects in insulin secretion and insulin action in non-insulin-dependent diabetes mellitus are inherited:Metabolic studies on offspring of diabetic probands.J Clin Invest,1998,101:86-96.
  • [7]Nagi Dk,Konwler WC,Mohamed AV,et al.Intact proinsulin,del 31,32 proinsulin,and specific insulin concentration among nondiabetic subjects in populations at varying risk of type 2 diabetes.Diabetes Care,1998,21:127-133.
  • [8]段宇,刘超,蒋须勤.胰岛β细胞相关转录因子的研究进展.中华糖尿病杂志,2004,12:63-64.
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